Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys.

@article{Grondin2002ChronicCG,
  title={Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys.},
  author={Richard C Grondin and Zhi-Ming Zhang and Ai Yi and Wayne A. Cass and Navin Maswood and Anders H. Andersen and Dennis D Elsberry and Michael C Klein and Greg A. Gerhardt and Don Marshall Gash},
  journal={Brain : a journal of neurology},
  year={2002},
  volume={125 Pt 10},
  pages={2191-201}
}
The powerful trophic effects that glial cell line-derived neurotrophic factor (GDNF) exerts on midbrain dopamine neurones suggest its use in treating Parkinson's disease. However, some important questions remain about the possible therapeutic applications of GDNF. Here we demonstrate that the chronic infusion of 5 or 15 micro g/day GDNF into the lateral ventricle or the striatum, using programmable pumps, promotes restoration of the nigrostriatal dopaminergic system and significantly improves… CONTINUE READING
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Neurogenesis in the adult mammalian substantia nigra [abstract

  • M Zhao, S Momma, K Delfani, CB Johansson, J Frisen, AM. Janson
  • Soc Neurosci Abstr
  • 2001
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