Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens

@inproceedings{Cai2013ChromothripsislikePA,
  title={Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens},
  author={Haoyang Cai and Nitin Kumar and Homayoun C. Bagheri and Christian von Mering and Mark D. Robinson and Michael Baudis},
  booktitle={BMC Genomics},
  year={2013}
}
Chromothripsis is a recently discovered phenomenon of genomic rearrangement, possibly arising during a single genome-shattering event. This could provide an alternative paradigm in cancer development, replacing the gradual accumulation of genomic changes with a “one-off” catastrophic event. However, the term has been used with varying operational definitions, with the minimal consensus being a large number of locally clustered copy number aberrations. The mechanisms underlying these… CONTINUE READING
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