Chromosomes with one, two, three, and four fetal globin genes: molecular and hematologic analysis.

  title={Chromosomes with one, two, three, and four fetal globin genes: molecular and hematologic analysis.},
  author={Adrian V S Hill and Donald K. Bowden and David J. Weatherall and John B. Clegg},
  volume={67 6},
Analysis of DNA from 852 Island Melanesians has revealed a high frequency of single- and triple-gamma-globin genes in this population. Homozygotes for triple- and single-gamma genes have normal hematologic findings, normal hemoglobin F (HbF) levels, and when there is coexisting alpha thalassemia, appropriate levels of Bart's Hb (gamma 4) at birth. In addition, we have identified an individual with a quadruple-gamma gene chromosome who also has a normal HbF level. All single-gamma genes were A… CONTINUE READING
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