Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.

@article{Krewson2004Chromosomes6A,
  title={Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains.},
  author={Thomas D Krewson and Pamela J. Supelak and Annie E Hill and Jonathan B. Singer and Eric S. Lander and Joseph H. Nadeau and Mark R. Palmert},
  journal={Endocrinology},
  year={2004},
  volume={145 10},
  pages={4447-51}
}
Variation in the onset of puberty among inbred strains of mice suggests that quantitative trait loci (QTLs) affect neurological and hormonal aspects of sexual maturation. Taking a novel approach toward identifying factors that regulate the hypothalamic-pituitary-gonadal (HPG) axis, we evaluated pubertal timing [as assessed by vaginal opening (VO)] in two… CONTINUE READING