Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum

  title={Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum},
  author={Jianbing Mu and Junhui Duan and Kateryna D. Makova and Deirdre A. Joy and Chuong Q. Huynh and Oralee H Branch and Wen-Hsiung Li and Xin-zhuan Su},
The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3,000–5,000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large effective population size. To test the hypothesis, we analysed single nucleotide… CONTINUE READING