Chromosome translocations and covert leukemic clones are generated during normal fetal development.

@article{Mori2002ChromosomeTA,
  title={Chromosome translocations and covert leukemic clones are generated during normal fetal development.},
  author={Hiroshi Mori and Susan M. Colman and Zhijian Xiao and Anthony M. Ford and Lyn E. Healy and Craig Donaldson and Jill M Hows and Cristina Navarrete and Mel Greaves},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 12},
  pages={8242-7}
}
Studies on monozygotic twins with concordant leukemia and retrospective scrutiny of neonatal blood spots of patients with leukemia indicate that chromosomal translocations characteristic of pediatric leukemia often arise prenatally, probably as initiating events. The modest concordance rate for leukemia in identical twins ( approximately 5%), protracted latency, and transgenic modeling all suggest that additional postnatal exposure and/or genetic events are required for clinically overt… CONTINUE READING
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