Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture.

@article{Cremer2000ChromosomeTI,
  title={Chromosome territories, interchromatin domain compartment, and nuclear matrix: an integrated view of the functional nuclear architecture.},
  author={Thomas Cremer and Gregor Kreth and Hubert Koester and Rainer H. A. Fink and Rainer Heintzmann and Marion Cremer and Irina Solovei and Daniele Zink and Christoph Cremer},
  journal={Critical reviews in eukaryotic gene expression},
  year={2000},
  volume={10 2},
  pages={179-212}
}
Advances in the specific fluorescent labeling of chromatin in fixed and living human cells in combination with three-dimensional (3D) and 4D (space plus time) fluorescence microscopy and image analysis have opened the way for detailed studies of the dynamic, higher-order architecture of chromatin in the human cell nucleus and its potential role in gene regulation. Several features of this architecture are now well established: 1. Chromosomes occupy distinct territories in the cell nucleus with… CONTINUE READING