Chromosome studies in the non-Hodgkin's lymphomas: the role of the 14;18 translocation.

@article{Rowley1988ChromosomeSI,
  title={Chromosome studies in the non-Hodgkin's lymphomas: the role of the 14;18 translocation.},
  author={Janet D. Rowley},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1988},
  volume={6 5},
  pages={919-25}
}
  • Janet D. Rowley
  • Published 1988 in
    Journal of clinical oncology : official journal…
The 14;18 translocation [t(14;18)] is the most common chromosome abnormality noted in the non-Hodgkin's lymphomas (NHL). Although the translocation is seen in various histologic subtypes, it is most commonly associated with the follicular lymphomas, especially the small-cleaved cell (FSC) and mixed-cell (FM) subtypes. The translocation breakpoint has been cloned and DNA probes from the junction on chromosome 18 can now be used to detect the genetic consequences of the translocation in tumors… CONTINUE READING

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