Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure

@article{Hbner2009ChromosomeSA,
  title={Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure},
  author={Benedikt H{\"u}bner and Hilmar Strickfaden and Stefan M{\"u}ller and Marion Cremer and Thomas Cremer},
  journal={European Biophysics Journal},
  year={2009},
  volume={38},
  pages={729-747}
}
Chromosome shattering has been described as a special form of mitotic catastrophe, which occurs in cells with unrepaired DNA damage. The shattered chromosome phenotype was detected after application of a methanol/acetic acid (MAA) fixation protocol routinely used for the preparation of metaphase spreads. The corresponding phenotype in the living cell and the mechanism leading to this mitotic catastrophe have remained speculative so far. In the present study, we used V79 Chinese hamster cells… CONTINUE READING

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