Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions


Genomes assembled de novo from short reads are highly fragmented relative to the finished chromosomes of Homo sapiens and key model organisms generated by the Human Genome Project. To address this problem, we need scalable, cost-effective methods to obtain assemblies with chromosome-scale contiguity. Here we show that genome-wide chromatin interaction data… (More)
DOI: 10.1038/nbt.2727


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