Chromosome rearrangements via template switching between diverged repeated sequences.

  title={Chromosome rearrangements via template switching between diverged repeated sequences.},
  author={Ranjith P. Anand and Olga Tsaponina and Patricia W. Greenwell and Cheng-Sheng Lee and Wei Du and Thomas D Petes and James E Haber},
  journal={Genes & development},
  volume={28 21},
Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy number changes. Although some of these rearrangements appear to involve nonhomologous end-joining, many must have involved mechanisms requiring new DNA synthesis. Models such as microhomology-mediated break-induced replication (MM-BIR) have been invoked to explain these rearrangements. We examined BIR and template switching between highly… CONTINUE READING
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