Chromosome rearrangements involved in the origin of trisomy 15 in spontaneous leukemia of AKR mice.


Trisomy 15, known to be the predominant chromosome abnormality in leukemic cells of the AKR strain, develops even in animals of the subline AKR/Rb1Ald with two constitutive Robertsonian translocation chromosomes (6.15). Among 10 leukemic animals of this subline exhibiting chromosomal anomalies, 6 showed trisomy of the whole Robertsonian translocation… (More)


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