Chromosome rearrangements induce both variegated and reduced, uniform expression of heterochromatic genes in a development-specific manner.

@article{Weiler1998ChromosomeRI,
  title={Chromosome rearrangements induce both variegated and reduced, uniform expression of heterochromatic genes in a development-specific manner.},
  author={Karen S. Weiler and Barbara T. Wakimoto},
  journal={Genetics},
  year={1998},
  volume={149 3},
  pages={1451-64}
}
In Drosophila melanogaster, chromosome rearrangements that juxtapose euchromatin and heterochromatin can result in position effect variegation (PEV), the variable expression of heterochromatic and euchromatic genes in the vicinity of the novel breakpoint. We examined PEV of the heterochromatic light (lt) and concertina (cta) genes in order to investigate potential tissue or developmental differences in chromosome structure that might be informative for comparing the mechanisms of PEV of… CONTINUE READING
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