Chromosome painting analysis of X-ray-induced aberrations in human lymphocytes in vitro.

@article{Matsuoka1994ChromosomePA,
  title={Chromosome painting analysis of X-ray-induced aberrations in human lymphocytes in vitro.},
  author={Atsuko Matsuoka and James D. Tucker and Makoto Hayashi and Naomi Yamazaki and Toshio Sofuni},
  journal={Mutagenesis},
  year={1994},
  volume={9 2},
  pages={151-5}
}
Chromosomal rearrangements in human lymphocytes induced by X-rays (0, 0.5, 1.0 and 2.0 Gray) were analyzed using chromosome painting. DNA probes for human chromosomes 1, 3 or 4 alone, and a combination of 1 and 4, were used for analysis. The frequency of cells with rearrangements, i.e. reciprocal translocations, dicentrics, insertions, tricentrics and fragments, involving chromosome 4 increased with dose in both 48 and 72 h cultures. The number of translocations per cell also increased with… CONTINUE READING

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