Chromosome organization and chromatin modification: influence on genome function and evolution

@article{Holmquist2006ChromosomeOA,
  title={Chromosome organization and chromatin modification: influence on genome function and evolution},
  author={Gerald P. Holmquist and Terry Ashley},
  journal={Cytogenetic and Genome Research},
  year={2006},
  volume={114},
  pages={96 - 125}
}
Histone modifications of nucleosomes distinguish euchromatic from heterochromatic chromatin states, distinguish gene regulation in eukaryotes from that of prokaryotes, and appear to allow eukaryotes to focus recombination events on regions of highest gene concentrations. Four additional epigenetic mechanisms that regulate commitment of cell lineages to their differentiated states are involved in the inheritance of differentiated states, e.g., DNA methylation, RNA interference, gene… Expand
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