Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines

@article{Shi2005ChromosomeNY,
  title={Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines},
  author={Q. Shi and R. King},
  journal={Nature},
  year={2005},
  volume={437},
  pages={1038-1042}
}
Although mutations in cell cycle regulators or spindle proteins can perturb chromosome segregation, the causes and consequences of spontaneous mitotic chromosome nondisjunction in human cells are not well understood. It has been assumed that nondisjunction of a chromosome during mitosis will yield two aneuploid daughter cells. Here we show that chromosome nondisjunction is tightly coupled to regulation of cytokinesis in human cell lines, such that nondisjunction results in the formation of… Expand
373 Citations
Cell biology: Nondisjunction, aneuploidy and tetraploidy
  • 57
  • PDF
When 2+2=5: the origins and fates of aneuploid and tetraploid cells.
  • R. King
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 2008
  • 94
The consequences of tetraploidy and aneuploidy
  • 315
  • PDF
Examining the link between chromosomal instability and aneuploidy in human cells
  • 447
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Securin Is Required for Chromosomal Stability in Human Cells
  • 368
  • PDF
Increased nondisjunction of chromosome 21 with age in human peripheral lymphocytes.
  • 20
Inactivation of hCDC4 can cause chromosomal instability
  • 540
Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations
  • 188
  • PDF
...
1
2
3
4
...