Chromosome motors on the move. From motion to spindle checkpoint activity.

  title={Chromosome motors on the move. From motion to spindle checkpoint activity.},
  author={St{\'e}phane Brunet and Isabelle Vernos},
  journal={EMBO reports},
  volume={2 8},
Spindle assembly and chromosome segregation require the concerted activities of a variety of microtubule-dependent motors. This review focuses on our current knowledge of the roles played by the chromosome-associated motors during mitosis. While some appear to function conventionally in moving chromosomes along microtubules others seem to act in different ways. For example, by docking microtubules to chromosome arms, chromatin-associated motors prevent chromosome loss and participate in spindle… CONTINUE READING
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