Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc

@article{Schwab1984ChromosomeLI,
  title={Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc},
  author={M. Schwab and H. Varmus and J. Bishop and K. Grzeschik and S. Naylor and A. Sakaguchi and G. Brodeur and J. Trent},
  journal={Nature},
  year={1984},
  volume={308},
  pages={288-291}
}
Cellular oncogenes comprise a class of genes whose aberrant expression or function may be involved in the development of tumours1. Indeed, several naturally occurring animal and human tumours are associated with consistent alterations in the structure or genomic position of particular cellular oncogenes2–4. Recently, we isolated a DNA segment having limited similarity to c-myc (termed N-myc) from a human neuroblastoma cell line5. Although N-myc was present as a single copy in normal cells, it… Expand
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.
Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas.
Gene amplification in human neuroblastomas: basic mechanisms and clinical implications.
N-myc amplification at chromosome band 1p32 in neuroblastoma cells as investigated by in situ hybridization
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