Chromosome instability in a calf with amelia of thoracic limbs.

@article{Szczerbal2006ChromosomeII,
  title={Chromosome instability in a calf with amelia of thoracic limbs.},
  author={Izabela Szczerbal and Tadeusz Stefaniak and Artur Dubiel and J. D. Siembieda and Wojciech Nizanski and Marek Switonski},
  journal={Veterinary pathology},
  year={2006},
  volume={43 5},
  pages={
          789-92
        }
}
We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). Cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and… CONTINUE READING
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