Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells.

@article{Lo2002ChromosomeIA,
  title={Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells.},
  author={Anthony Wing Ip Lo and Carl N. Sprung and Bijan Fouladi and Mehrdad Pedram and Laure Sabatier and Michelle Ricoul and Gloria E Reynolds and John P. Murnane},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 13},
  pages={4836-50}
}
Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated with tumorigenesis. To determine the relationship between telomere loss and chromosome instability in mammalian cells, we investigated the events resulting from the introduction of a double-strand break near a telomere with I-SceI endonuclease in mouse embryonic stem cells. The inactivation of a… CONTINUE READING