Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs.

@article{Takata2001ChromosomeIA,
  title={Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs.},
  author={Minoru Takata and Masao S. Sasaki and Seiji Tachiiri and Tatsuya Fukushima and Eiichiro Sonoda and David Schild and Larry H. Thompson and Shunichi Takeda},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 8},
  pages={2858-66}
}
The Rad51 protein, a eukaryotic homologue of Escherichia coli RecA, plays a central role in both mitotic and meiotic homologous DNA recombination (HR) in Saccharomyces cerevisiae and is essential for the proliferation of vertebrate cells. Five vertebrate genes, RAD51B, -C, and -D and XRCC2 and -3, are implicated in HR on the basis of their sequence similarity to Rad51 (Rad51 paralogs). We generated mutants deficient in each of these proteins in the chicken B-lymphocyte DT40 cell line and report… CONTINUE READING
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