Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.

@article{Kim2008ChromosomeFA,
  title={Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.},
  author={Hyun-Min Kim and Vidhya Narayanan and Piotr A. Mieczkowski and Thomas D Petes and Maria M. Krasilnikova and Sergei M Mirkin and Kirill S Lobachev},
  journal={The EMBO journal},
  year={2008},
  volume={27 21},
  pages={2896-906}
}
Expansion of triplex-forming GAA/TTC repeats in the first intron of FXN gene results in Friedreich's ataxia. Besides FXN, there are a number of other polymorphic GAA/TTC loci in the human genome where the size variations thus far have been considered to be a neutral event. Using yeast as a model system, we demonstrate that expanded GAA/TTC repeats represent a threat to eukaryotic genome integrity by triggering double-strand breaks and gross chromosomal rearrangements. The fragility potential… CONTINUE READING
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