Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis

@article{Marshall2001ChromosomeEA,
  title={Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis},
  author={Wallace F. Marshall and John Frederick Daniel Marko and David A. Agard and John Sedat},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={569-578}
}
BACKGROUND Mitosis involves the interaction of many different components, including chromatin, microtubules, and motor proteins. Dissecting the mechanics of mitosis requires methods of studying not just each component in isolation, but also the entire ensemble of components in its full complexity in genetically tractable model organisms. RESULTS We have developed a mathematical framework for analyzing motion in four-dimensional microscopy data sets that allows us to measure elasticity… CONTINUE READING

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