Chromosome damage induced by carboplatin (CBDCA).

  title={Chromosome damage induced by carboplatin (CBDCA).},
  author={M G Gonz{\'a}lez Cid and Marta Dolores Mudry and I Larripa},
  journal={Toxicology letters},
  volume={76 2},
The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this highest dose a significant increase was induced in the value of micronuclei (MN) and an important delay in the lymphocyte cycle progression was observed. In Chinese hamster ovary… CONTINUE READING