Chromosome damage and second malignancy in patients treated with melphalan.

@article{Lambert1986ChromosomeDA,
  title={Chromosome damage and second malignancy in patients treated with melphalan.},
  author={B J Lambert and Kerstin Holmberg and Nina Einhorn},
  journal={IARC scientific publications},
  year={1986},
  volume={78},
  pages={147-60}
}
Cytogenetic studies were carried out on peripheral lymphocytes from cancer patients at different times after therapy with melphalan. The frequency of sister chromatid exchange (SCE) was increased markedly shortly after treatment, and then declined to near pretreatment levels over a four-week period. In-vitro studies showed that the SCE frequency induced by melphalan is reduced slowly in resting G0 lymphocytes and considerably faster in mitogen-stimulated G1 cells. The results demonstrate that… CONTINUE READING