Chromosome copies and consequences

  title={Chromosome copies and consequences},
  journal={Trends in genetics : TIG},
  volume={16 10},
Aneuploidy refers to an increase or decrease in the normal chromosome complement by one or more chromosomes. A well-known case of aneuploidy in humans is trisomy for chromosome 21, the cause of Down syndrome. Changes in chromosome copy number are widely recognized as a class of mutation in human cells and the mechanisms leading to genome instability are the subject of intense investigation. The yeast Saccharomyces cerevisiae has provided especially fertile ground for studying mechanisms… CONTINUE READING

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