Chromosome cohesion decreases in human eggs with advanced maternal age.

Abstract

Aneuploidy in human eggs increases with maternal age and can result in infertility, miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however, are largely unknown especially in the human where eggs are exceedingly rare and precious. We obtained human eggs from subjects ranging from 16.4 to 49.7 years old following in vitro… (More)
DOI: 10.1111/j.1474-9726.2012.00866.x

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Cite this paper

@article{Duncan2012ChromosomeCD, title={Chromosome cohesion decreases in human eggs with advanced maternal age.}, author={Francesca E. Duncan and Jessica E. Hornick and Michael A Lampson and Richard M Schultz and Lonnie D Shea and Teresa K. Woodruff}, journal={Aging cell}, year={2012}, volume={11 6}, pages={1121-4} }