Chromosome breakpoint distribution of damage induced in peripheral blood lymphocytes by densely ionizing radiation.


PURPOSE To assess the chromosomal breakpoint distribution in human peripheral blood lymphocytes (PBL) after exposure to a low dose of high linear energy transfer (LET) alpha-particles using the technique of multiplex fluorescence in situ hybridization (m-FISH). MATERIALS AND METHODS Separated PBL were exposed in G0 to 0.5 Gy 238Pu alpha-particles… (More)


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