Chromosome anomalies and Y chromosome microdeletions as causal factors in male infertility.

@article{Chandley1998ChromosomeAA,
  title={Chromosome anomalies and Y chromosome microdeletions as causal factors in male infertility.},
  author={Ann C. Chandley},
  journal={Human reproduction},
  year={1998},
  volume={13 Suppl 1},
  pages={
          45-50
        }
}
  • A. Chandley
  • Published 1 April 1998
  • Biology
  • Human reproduction
Among the 10% or so of men who are diagnosed as oligo- or azoospermic in the absence of any physical obstruction, research is now showing that between 8 and 15% carry a microdeletion in the long arm of the Y chromosome which, by loss of specific DNA segments, leads to loss of vital genes for sperm production. Chromosomal anomalies account for approximately 2% of all men who attend infertility clinics, rising to 15% among those with azoospermia. There are serious implications for couples seeking… 
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