Chromosome aneuploidy in the spermatozoa of two men with globozoospermia.

@article{Morel2004ChromosomeAI,
  title={Chromosome aneuploidy in the spermatozoa of two men with globozoospermia.},
  author={F Morel and Nathalie Douet-Guilbert and Alexandre Moerman and Benjamin Duban and Carole Marchetti and Bruno Delobel and M-J Le Bris and V{\'e}ronique Amice and Marc de Braekeleer},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 11},
  pages={
          835-8
        }
}
The objective of this study was to determine the aneuploidy level in spermatozoa in two men with globozoospermia. Sperm nuclei were analysed by fluorescence in-situ hybridization (FISH) in two infertile males with globozoospermia. Dual FISH for chromosomes 7 and 9, 13 and 21, and triple FISH for chromosomes X, Y, and 18 was performed. The main outcome measured was meiotic segregation differences between both globozoospermic men and controls. A statistically significant difference in disomies 13… CONTINUE READING

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