Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies.

@article{Blazak1986ChromosomeAO,
  title={Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies.},
  author={W. F. Blazak and Bernard E. Stewart and Igal Galperin and Kathryn L. Allen and Colette J. Rudd and Ann D. Mitchell and William J. Caspary},
  journal={Environmental mutagenesis},
  year={1986},
  volume={8 2},
  pages={
          229-40
        }
}
Cells from small (sigma) and large (lambda) trifluorothymidine-resistant (TFTr) colonies induced by chemical mutagen treatment of TK+/-L5178Y mouse lymphoma cells were examined for chromosomal abnormalities. Analysis of G-banded metaphase chromosomes from 34 sigma-TFTr colonies revealed that cells from 20 (59%) possessed one or more chromosomal abnormalities. The most frequent (16/20 colonies) abnormality observed in cells from sigma-TFTr colonies involved the addition of extra chromatin to the… CONTINUE READING

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