Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases.

@article{Nelson2000ChromosomeAI,
  title={Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases.},
  author={Mark A. Nelson and Michael D. Radmacher and Rodney Simon and Mikel Aickin and Jin M in Yang and Luzizila Helena Panda and J. Terry Emerson and Dusten Roe and Laskus Adair and Fabiano Lopes Thompson and Jerry Bangert and Stanley P. L. Leong and Raymond Taetle and Stuart Salmon and Jeffrey M. Trent},
  journal={Cancer genetics and cytogenetics},
  year={2000},
  volume={122 2},
  pages={
          101-9
        }
}
We report the cytogenetic abnormalities from a series of 206 primary malignant melanoma specimens referred to a single institution. A total of 169 out of 206 unique cases had chromosome breakpoints. A previously described statistical method was used to detect nonrandom distribution of chromosome breakpoints at the level of chromosome regions. Nonrandom occurrence of chromosome breakpoints (indicating that the observed number of breaks significantly exceeded the expected number of breaks) was… CONTINUE READING

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