Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene.

Abstract

Chronic exposure to 1,3-butadiene (BD) results in a marked increase in the incidence of thymic lymphoma in male B6C3F1 relative to NIH Swiss mice whereas no demonstrable differences in bone marrow (target organ) toxicity exist. Repeated exposure to BD is known to produce a macrocytic anemia and an increase in the frequency of micronuclei in circulating… (More)

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@article{Irons1987ChromosomeAI, title={Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene.}, author={Richard D. Irons and Mitsuo Oshimura and Jeffrey C Barrett}, journal={Carcinogenesis}, year={1987}, volume={8 11}, pages={1711-4} }