Chromosome Structuring Limits Genome Plasticity in Escherichia coli

@article{Esnault2007ChromosomeSL,
  title={Chromosome Structuring Limits Genome Plasticity in Escherichia coli},
  author={Emilie Esnault and M. J. D. Valens and Olivier Esp{\'e}li and Fr{\'e}d{\'e}ric Boccard},
  journal={PLoS Genetics},
  year={2007},
  volume={3},
  pages={19 - 37}
}
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different parameters, including DNA replication, compositional skew of replichores, coordination of gene expression with DNA replication, replication-associated gene dosage, and chromosome organization into macrodomains. Chromosomes were rearranged by… CONTINUE READING

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