Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

@article{Dobles2000ChromosomeMA,
  title={Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2},
  author={Max Dobles and Vasco Liberal and Martin L. Scott and Robert Benezra and Peter K. Sorger},
  journal={Cell},
  year={2000},
  volume={101},
  pages={635-645}
}
The initiation of chromosome segregation at anaphase is linked by the spindle assembly checkpoint to the completion of chromosome-microtubule attachment during metaphase. To determine the function of the mitotic checkpoint protein Mad2 during normal cell division and when mitosis goes awry, we have knocked out Mad2 in mice. We find that E5.5 embryonic cells lacking Mad2, like mad2 yeast, grow normally but are unable to arrest in response to spindle disruption. At E6.5, the cells of the epiblast… CONTINUE READING
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