Chromosome Fragmentation after Induction of a Double-Strand Break Is an Active Process Prevented by the RMX Repair Complex

@article{Lobachev2004ChromosomeFA,
  title={Chromosome Fragmentation after Induction of a Double-Strand Break Is an Active Process Prevented by the RMX Repair Complex},
  author={Kirill S Lobachev and Eric A Vitriol and Jennifer K Stemple and Michael A. Resnick and Kerry Bloom},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={2107-2112}
}
Chromosome aberrations are common outcomes of exposure to DNA-damaging agents or altered replication events and are associated with various diseases and a variety of carcinomas, including leukemias, lymphomas, sarcomas, and epithelial tumors. The incidence of aberrations can be greatly increased as a result of defects in DNA repair pathways. Although there is considerable information about the molecular events associated with the induction and repair of a double-strand break (DSB), little is… CONTINUE READING
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