Chromosome Compaction by Active Loop Extrusion.

  title={Chromosome Compaction by Active Loop Extrusion.},
  author={Anton Goloborodko and John Frederick Daniel Marko and Leonid A. Mirny},
  journal={Biophysical journal},
  volume={110 10},
During cell division, chromosomes are compacted in length by more than a 100-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ∼100 kb loops. The mechanism underlying the active process of chromosome compaction into a stack of loops is unknown. Here we test the hypothesis that chromosomes are compacted by enzymatic machines that actively extrude chromatin loops. When such loop-extruding factors (LEF… CONTINUE READING
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