Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene.

@article{Puig1995Chromosome9D,
  title={Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene.},
  author={Susana Puig and Anna Matas Jos{\'e} Luis Raymond Mar Gonz{\'a}lez - Savignat Ad Ruiz and Conxi L{\'a}zaro and Teresa Castel and Michael Lynch and Jos{\'e} Palou and Antoni Vilalta and Jean Weissenbach and Jos{\'e} Manuel Mascar{\'o} and Xavier Estivill},
  journal={American journal of human genetics},
  year={1995},
  volume={57 2},
  pages={395-402}
}
We have analyzed 12 microsatellite markers on chromosome 9p in 54 paired cutaneous malignant melanoma (CMM) tumors and normal tissues. Forty-six percent of the tumors, including two in situ CMMs, showed loss of heterozygosity (LOH) at 9p. Only one tumor was homozygously deleted for 9p markers. The smallest deleted region was defined by five tumors and included markers D9S126 to D9S259. Loss of eight or more markers correlated significantly with worse prognosis (P < .002). Among the primary… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Cross‐species models of human melanoma

The Journal of pathology • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…