Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.

  title={Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.},
  author={Jielin Sun and Ethan M. Lange and Sarah D. Isaacs and Wennuan Liu and Kathleen E. Wiley and Leslie A. Lange and Henrik Gronberg and David Duggan and John D. Carpten and Patrick Walsh and Jianfeng Xu and Bao-li Chang and William B Isaacs and S{\'i}qun Lilly Zheng},
  journal={The Prostate},
  volume={68 5},
BACKGROUND Multiple variants in three regions at 8q24 are consistently found to be associated with prostate cancer (PCa) risk in population-based association studies. The role that these variants may play in familial prostate cancer risk has not been extensively investigated. METHODS We evaluated 12 SNPs at three 8q24 regions using population-based association and family-based linkage and association methods in hereditary PCa (HPC) probands and their families, non-HPC patients, and unaffected… CONTINUE READING
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