Chromosome 8p11.2 translocations: Prevalence, FISH analysis for FGFR1 and MYST3, and clinicopathologic correlates in a consecutive cohort of 13 cases from a single institution

@article{Patnaik2010Chromosome8T,
  title={Chromosome 8p11.2 translocations: Prevalence, FISH analysis for FGFR1 and MYST3, and clinicopathologic correlates in a consecutive cohort of 13 cases from a single institution},
  author={Mrinal M. Patnaik and Naseema Gangat and Ryan A. Knudson and Jeannette G. Keefe and Curtis A Hanson and Animesh D Pardanani and Rhett P Ketterling and Ayalew Tefferi},
  journal={American Journal of Hematology},
  year={2010},
  volume={85}
}
Chromosome 8p11.2 translocations result in diverse oncogenic fusion genes involving FGFR1 or MYST3. [] Key Result Among 24,262 unique patient cytogenetic studies performed at the Mayo Clinic, 8p11.2 translocations were identified in 14 cases ( approximately 0.06%). FISH analysis was performed in 13 patients (12 had myeloid neoplasms) and revealed abnormalities of MYST3 (n = 4) or FGFR1 (n = 4) in eight patients. MYST3 abnormalities were associated with acute myeloid leukemia (AML), M4 in three and M6 in one…

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