Chromosome 21 and the cell growth inhibitory effect of human interferon preparations

@article{Tan1976Chromosome2A,
  title={Chromosome 21 and the cell growth inhibitory effect of human interferon preparations},
  author={Y. H. Tan},
  journal={Nature},
  year={1976},
  volume={260},
  pages={141-143}
}
  • Y. H. Tan
  • Published 11 March 1976
  • Biology, Medicine
  • Nature
INTERFERONS constitute a class of biologically active glycoproteins1–3 which induce a spectrum of physiological changes in living cells, leading to the inhibition of virus replication4, of cell growth in vitro—both normal and tumour cells5,8—and of tumour growth in vivo9–15. The mechanism(s) underlying these effects is unknown. Gressor et al. have suggested that the same molecule in an interferon preparation is responsible for both the antiviral (AV) and cell growth inhibitory (CGI) effect5… Expand
Interferon suppresses the transition of quiescent 3T3 cells to a growing state
TLDR
A suppressive effect of interferon on the transition from the quiescent to the growing state in BALB/c 3T3 cells is described and the data indicate that Interferon suppresses the initiation of DNA synthesis. Expand
Interferon and Its Inducers
TLDR
Investigations of the mechanisms which underlie the induction and the actions of interferons have led to novel insights into the regulation of gene expression in eukaryotic cells as well as into the pathophysiology of viral diseases. Expand
Identification of the cell multiplication inhibitory factors in interferon preparations as interferons
TLDR
It is provided strong evidence that the antiviral and CMI activities of interferon preparations are indeed intrinsic properties of the covalent structure ofinterferons. Expand
The Interferon System in Physiology and Medicine
TLDR
The bewildering range of effects of IFN is indicated, which shows the same cell, stimulated with different inducers, can produce different IFNs which have similar spectrums of antiviral activity but differ in antigenic, physicochemical and biological properties. Expand
Synthesis of interferon-induced polypeptides in normal and chromosome 21-aneuploid human fibroblasts: relationship to relative sensitivities in antiviral assays.
TLDR
The amplified effect of aneuploidy as measured in the antiviral response appears to result from some step subsequent to synthesis ofinterferon receptors and formation of interferon-receptor complexes. Expand
Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome
TLDR
It is found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons, and it is suggested that this property is also regulated by genes on chromosome 21. Expand
[79] Selection and screening of transformed NIH3T3 cells for enhanced sensitivity to human interferons α and β
TLDR
The aim of the selection procedure is to optimize conditions for a transformant with increased sensitivity to human interferon to survive, thus enriching for transformants with enhanced sensitivity tohuman α and β interferOn, the endpoint is the interfer on which selection for the entire transformants take place. Expand
The synthesis and actions of mouse and human interferons in mouse-human hybrid cells.
TLDR
In one of the hybrid cell lines capable of producing both mouse and human interferons, the proportion of theTwo interferon activities produced varied greatly under different inducing conditions, suggesting that there are differences in the triggering mechanisms of the two interferONS. Expand
The Comparative Biology of Immune and Classical Interferons
TLDR
The comparison of classical and immune interferon with regard to production, characterization, mechanism of action, role as an antiviral agent, effects on the immune response, and other nonantiviral effects is discussed. Expand
Enhanced expression of cellular receptors for human interferon α on peripheral lymphocytes from patients with down's syndrome
TLDR
It is shown that lymphocytes from patients with Down’s syndrome show an increased specific binding of 1251-H~ IFNo compared to lymphocyte from normal donors, and norms for the affinity of binding and the interferon receptor concentration are provided that may prove useful in investigating theInterferon sensitivity of peripheral blood lymphocytesfrom patients with other diseases. Expand
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References

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Interferon and Cell Division VII. Inhibitory Effect of Highly Purified Interferon Preparations on the Multiplication of Leukemia L 1210 Cells
TLDR
Highly purified mouse interferon preparations prepared by different techniques in different laboratories inhibited the mul–tiplication of mouse leukemia L 1210 cells, and it seems reasonable to conclude thatInterferon itself can inhibit cell multiplication. Expand
Chromosome-21-dosage effect on inducibility of anti-viral gene(s).
TLDR
Evidence is found to suggest that the regulation of ithe anti-viral genes in human cells is controlled by regulatory gene element(s) located on a separate chromosome. Expand
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
The effect of interferon on expression of Epstein-Barr virus (EBV) early gene functions was investigated. The 'early antigen' synthesis which follows either EBV superinfection of established lymphoidExpand
Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.
TLDR
The factor in interferon preparations responsible for this effect was trypsin-sensitive, pH 2-stable, and nonsedimentable at 105,000 g ; it could not be separated from the interfering principle itself. Expand
INTERFERON AND CELL DIVISION : III. Effect of Interferon on the Division Cycle of L1210 Cells In Vitro
TLDR
The results of experiments designed to test each of the possibilities for the inhibitory effect of interferon on the division cycle of L1210 cells are presented. Expand
Chromosomal localization of human genes governing the interferon-induced antiviral state.
TLDR
Data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. Expand
Chemical carcinogenesis in mice inhibited by interferon.
TLDR
Study with CF-1 mice is reported to determine the effects of interferon on SC tumour induction by 3-methylcholanthrene (3-MC), which was previously shown to harbour high levels of type C RNA gs antigen. Expand
Inhibition of Spontaneous Mammary Carcinoma of Mice by Treatment with Interferon and Poly I:C 1
  • P. Came, D. Moore
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1971
TLDR
This preliminary study employed RIII mice, a strain in which approximately 90% of the females spontaneously develop mammary adenocarcinomas, and observed the appearance of MTV in milk and for the rate and incidence of mammary tumor development. Expand
THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21
TLDR
It is apparent from these findings that the gene(s) for indophenol oxidase (IPO-B) and the gene for the antiviral protein are syntenic and that they are linked to human chromosome G-21. Expand
Mechanism of the Antitumour Effect of Interferon in Mice
TLDR
Infection of mouse interferon preparations inhibits the growth of several murine transplantable tumours and increases the survival of tumour inoculated mice, and enhances in some manner the capacity of the host to reject the transplanted tumour. Expand
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