Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.

  title={Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.},
  author={Liisa Myllykangas and Fabienne Wavrant-De Vri{\`e}ze and Tuomo M. Polvikoski and Irma-Leena K Notkola and Raimo O Sulkava and Leena Niinist{\"o} and Steven Edland and Sampath Arepalli and Omanma Adighibe and Danielle Compton and John S. Hardy and Matti J Haltia and Pentti J. Tienari},
  journal={Journal of the neurological sciences},
  volume={236 1-2},
Genetic linkage studies have provided evidence for a late-onset Alzheimer's disease (AD) susceptibility locus on chromosome 21q. We have tested, in a two-stage association study, whether allelic or haplotype variation of the beta-amyloid cleaving enzyme-2 (BACE2) locus on chromosome 21q affects the risk of late-onset AD. In stage-1, an unselected population-based sample of Finns aged 85 years or over (n=515) was analysed. Neuropathologic examination including beta-amyloid load quantification… CONTINUE READING
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ApoE e3 haplotype modulates Alzheimer’s beta-amyloid deposition in the brain

  • L Myllykangas, T Polvikoski, K Reunanen, F Wavrant-de Vrieze, C Ellis, D Hernandez
  • Am J Med Genet
  • 2002
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