Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism.

@article{Tseng2014Chromosome1O,
  title={Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism.},
  author={Yi-Hsin Tseng and Po-Yuan Ke and Chia-Jung Liao and S I Wu and Hsiang-Cheng Chi and Chung-Ying Tsai and Cheng-Yi Chen and Yang-Hsiang Lin and Kwang-Huei Lin},
  journal={Autophagy},
  year={2014},
  volume={10 1},
  pages={20-31}
}
The thyroid hormone, T 3, regulates cell growth, differentiation and development through binding to the nuclear thyroid hormone receptor (THR), a member of the steroid/TR superfamily of ligand-dependent transcriptional factors. T 3 modulates lipid metabolism in liver, although the detailed molecular mechanisms are unclear at present. Here, by a microarray analysis, we identified a novel chromosome 19 open reading frame 80 (C19orf80) which was activated by T 3. T 3 stimulation led to… CONTINUE READING

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