Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1.

@article{Rasmussen2000Chromosome1L,
  title={Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1.},
  author={Sonja A Rasmussen and John W. Overman and Scott A. Thomson and Steven D. Colman and Corinne R Abernathy and R E Trimpert and Rebecca E Moose and Gurpreet Virdi and Kyle J. Roux and Manfred Bauer and Amyn M Rojiani and B. L. Maria and David James Muir and Margaret R. Wallace},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={28 4},
  pages={
          425-31
        }
}
Neurofibromatosis type 1 (NF1) is a common autosomal dominant condition characterized by benign tumor (neurofibroma) growth and increased risk of malignancy. Dermal neurofibromas, arising from superficial nerves, are primarily of cosmetic significance, whereas plexiform neurofibromas, typically larger and associated with deeply placed nerves, extend into contiguous tissues and may cause serious functional impairment. Malignant peripheral nerve sheath tumors (MPNSTs) seem to arise from plexiform… CONTINUE READING
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