Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD.

@article{Bird1997Chromosome1A,
  title={Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD.},
  author={Thomas Bird and Ellen M. Wijsman and David Nochlin and Maureen A. Leehey and S. Mark Sumi and Haydeh Payami and Parvoneh Poorkaj and E J Nemens and M Rafkind and Gerard D. Schellenberg},
  journal={Neurology},
  year={1997},
  volume={48 4},
  pages={949-54}
}
Several previous families with differing clinical and pathologic characteristics have demonstrated linkage to the 17q21-22 region. We have performed a linkage analysis with chromosome 17 markers on three families showing autosomal dominant inheritance of non-Alzheimer dementia and 60 kindreds with late-onset familial Alzheimer's disease (FAD). Family A shows unequivocal evidence of linkage with a maximum lod score of 5.0 for marker D17S934 (theta = 0.001). This family has an unusual syndrome of… CONTINUE READING

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