Chromosome 16 tumor-suppressor genes in breast cancer.

  title={Chromosome 16 tumor-suppressor genes in breast cancer.},
  author={Emad A Rakha and Andrew Russell Green and Des Powe and Rebecca R Roylance and Ian O. Ellis},
  journal={Genes, chromosomes & cancer},
  volume={45 6},
Loss of heterozygosity on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, suggesting the presence of one or more classic tumor-suppressor genes (TSGs). It has been shown that E-cadherin is the TSG on 16q in lobular tumors. In a search for the target genes in more frequently occurring low-grade nonlobular tumors, the smallest region of overlap (SRO) in this area of the genome has been exhaustively searched for. However, the results have demonstrated… CONTINUE READING

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