Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis.

@article{KorenMichowitz2007Chromosome1D,
  title={Chromosome 13q deletion and IgH abnormalities may be both masked by near-tetraploidy in a high proportion of multiple myeloma patients: a combined morphology and I-FISH analysis.},
  author={Maya Koren-Michowitz and Izhar Hardan and Janina Berghoff and Galina Yshoev and Ninette Amariglio and Gideon Rechavi and Arnon Nagler and L. Ya. Trakhtenbrot},
  journal={Cancer letters},
  year={2007},
  volume={255 2},
  pages={307-14}
}
Ploidy status and chromosomal aberrations involving chromosome 13q and the immunoglobulin heavy chain locus (IgH) are important prognostic features in multiple myeloma (MM). However, conventional cytogenetic studies are often not reveling and determination of plasma cells (PC) ploidy status in MM is technically difficult. We have used a combined cell morphology and interphase FISH (I-FISH) analysis in 184 consecutive BM samples from 136 MM patients for the diagnosis of chromosome 13q deletion… CONTINUE READING