Chromosome 11q13 markers and D-type cyclins in breast cancer

  title={Chromosome 11q13 markers and D-type cyclins in breast cancer},
  author={Gordon G Peters and Vera Fantl and Rosalind Smith and Sharon M. Brookes and Clive Dickson},
  journal={Breast Cancer Research and Treatment},
One in six primary human breast cancers has DNA amplification centered on the cyclin D1 gene (CCND1) on chromosome 11q13. This genetic abnormality is preferentially associated with estrogen-receptor positive tumors and may define a sub-class of patients with an adverse prognosis. AlthoughCCND1 has the credentials of a cellular oncogene, being a target for chromosomal translocation and retroviral integration, the 11q13 amplicon encompasses several other markers andCCND1 is not the only candidate… CONTINUE READING


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The product of the EMS 1 gene , amplified and overexpressed in human carcinomas , is homologous to a v - src substrate and is located in cell - substratum contact sites

  • C Gillett, V Fantl, +5 authors G Peters
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