Chromosomally encoded ampC-type beta-lactamase in a clinical isolate of Proteus mirabilis.

@article{Bret1998ChromosomallyEA,
  title={Chromosomally encoded ampC-type beta-lactamase in a clinical isolate of Proteus mirabilis.},
  author={Laurent Bret and C. Chanal-Claris and Danielle Sirot and El Bachir Chaibi and R. Labia and J. Sirot},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 5},
  pages={1110-4}
}
A clinical strain of Proteus mirabilis (CF09) isolated from urine specimens of a patient displayed resistance to amoxicillin (MIC >4,096 microg/ml), ticarcillin (4,096 microg/ml), cefoxitin (64 microg/ml), cefotaxime (256 microg/ml), and ceftazidime (128 microg/ml) and required an elevated MIC of aztreonam (4 microg/ml). Clavulanic acid did not act synergistically with cephalosporins. Two beta-lactamases with apparent pIs of 5.6 and 9.0 were identified by isoelectric focusing on a gel… CONTINUE READING
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