Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions

@inproceedings{Ueyama2012ChromosomalVO,
  title={Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions},
  author={Hanae Ueyama and Tomohisa Horibe and Shiro Hinotsu and Tomoaki Tanaka and Takeomi Inoue and Hisashi Urushihara and Akira Kitagawa and Koji Kawakami},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
Bone marrow derived human mesenchymal stem cells (hMSCs) have attracted great interest from both bench and clinical researchers because of their pluripotency and ease of expansion ex vivo. However, these cells do finally reach a senescent stage and lose their multipotent potential. Proliferation of these cells is limited up to the time of their senescence, which limits their supply, and they may accumulate chromosomal changes through ex vivo culturing. The safe, rapid expansion of hMSCs is… CONTINUE READING
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